Amination Reactions of Aryl Halides with Nitrogen-Containing Reagents Mediated by Palladium/Imidazolium Salt Systems
Gabriela A. Grasa, Mihai S. Viciu, Jinkun Huang and Steven P. Nolan*
*Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, United States, Email: steven.nolanugent.be
G. A. Grasa, M. S. Viciu, J. Huang, S. P. Nolan, J. Org. Chem., 2001, 66, 7714-7722.
DOI: 10.1021/jo010613+
see article for more reactions
Abstract
The Pd2(dba)3/IPr·HCl (1, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) system offers a very high activity in amination reactions involving aryl chlorides, aryl bromides, and aryl iodides with various nitrogen-containing substrates. The ligand is also effective for the synthesis of benzophenone imines, which can be easily converted to the corresponding primary amines by acid hydrolysis.
see article for more examples
IPr
J. Huang, G. Grasa, S. P. Nolan, Org. Lett., 1999, 1, 1307-1309.
Key Words
arylamines, anilines, Buchwald-Hartwig coupling
ID: J42-Y2001