Synthesis of 2-Alkoxy-Substituted Thiophenes, 1,3-Thiazoles, and Related S-Heterocycles via Lawesson's Reagent-Mediated Cyclization under Microwave Irradiation: Applications for Liquid Crystal Synthesis
Andre A. Kiryanov, Paul Sampson* and Alexander J. Seed*
*Department of Chemistry, Kent State University, Kent, Ohio 44242, Email: psampsonkent.edu, aseedkent.edu
A. A. Kiryanov, P. Sampson, A. J. Seed, J. Org. Chem., 2001, 66, 7925-7929.
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When the Lawesson’s reagent mediated cyclization of various 1,4-dicarbonyl compounds is performed under microwave irradiation conditions in a conventional microwave oven, high yields of the desired S-heterocycles are obtained, little or no byproduct is formed, reaction times are extremely short, and no solvent is needed for the reaction.
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