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Silica-Supported TEMPO Catalysts:  Synthesis and Application in the Anelli Oxidation of Alcohols

Thomas Fey, Holger Fischer, Stefan Bachmann, Klaus Albert and Carsten Bolm*

*Institut für Organische Chemie der Rheinisch-Westfälischen Technischen Hochschule Aachen, Landoltweg 1, 52056 Aachen, Germany, Email:

T. Fey, H. Fischer, S. Bachmann, K. Albert, C. Bolm, J. Org. Chem., 2001, 66, 8154-8159.

DOI: 10.1021/jo010535q

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Silica-supported TEMPO is easily obtained in a one-step reductive amination procedure starting from a commercially available aminopropyl-functionalized silica. This supported catalyst mediates the Anelli oxidation of various alcohols. The recyclability and stability of the applied silica-supported TEMPO have been studied.

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Catalytic Synthesis of Aldehydes and Ketones under Mild Conditions Using TEMPO/Oxone

C. Bolm, A. S. Magnus, J. P. Hildebrand, Org. Lett., 2000, 2, 1173-1175.

Key Words

Ketones, Aldehydes, TEMPO, Sodium Hypochlorite

ID: J42-Y2001