Indole Synthesis via Palladium-Catalyzed Intramolecular Cyclization of Alkynes and Imines
Akira Takeda, Shin Kamijo and Yoshinori Yamamoto
*Department of Chemistry, Graduate School of Science Tohoku University, Sendai 980-8578, Japan,
Email: yoshi
dlut.edu.cn
A. Takeda, S. Kamijo, Y. Yamamoto, J. Am. Chem. Soc., 2000, 122, 5662-5663.
DOI: 10.1021/ja000390p
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Abstract
In an entirely new palladium-catalyzed indole synthesis, 2-(1-alkynyl)-N-alkylideneanilines
provide 2-substituted-3-(1-alkenyl)indoles in good yields. The bond formation
takes place between C-2
and C-3.
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proposed mechanism
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Key Words
ID: J48-Y2000
