Organic Chemistry Portal



Indole Synthesis via Palladium-Catalyzed Intramolecular Cyclization of Alkynes and Imines

Akira Takeda, Shin Kamijo and Yoshinori Yamamoto

*Department of Chemistry, Graduate School of Science Tohoku University, Sendai 980-8578, Japan, Email:

A. Takeda, S. Kamijo, Y. Yamamoto, J. Am. Chem. Soc., 2000, 122, 5662-5663.

DOI: 10.1021/ja000390p

see article for more reactions


In an entirely new palladium-catalyzed indole synthesis, 2-(1-alkynyl)-N-alkylideneanilines provide 2-substituted-3-(1-alkenyl)indoles in good yields. The bond formation takes place between C-2
and C-3.

see article for more examples

proposed mechanism

Key Words


ID: J48-Y2000