Novel α-Amino Acid-Based Hydroxamic Acid Ligands for Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols
Yujiro Hoshino and Hisashi Yamamoto*
*Graduate School of Engineering, Nagoya University CREST, Japan Science and Technology Corporation (JST) Furo-cho, Chikusa, Nagoya 464-8603, Japan, Email: yamamotouchicago.edu
Y. Hoshino, H. Yamamoto, J. Am. Chem. Soc., 2000, 122, 10452-10453.
Chiral amino acid-based hydroxamic acids can be effective asymmetric catalysts for the epoxidation of allylic alcohols, especially disubstituted allylic alcohols. The mild reaction conditions, e.g., reasonable temperature, low degree of catalyst loading, and halogen-free solvent, extend the scope of this process.
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