Organic Chemistry Portal



Highly Effective Chiral Dipyridylphosphine Ligands:  Synthesis, Structural Determination, and Applications in the Ru-Catalyzed Asymmetric Hydrogenation Reactions

Cheng-Chao Pai, Ching-Wen Lin, Chi-Ching Lin, Chih-Chiang Chen, Albert S. C. Chan* and Wing Tak Wong

*Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong, China, Email:

C.-C. Pai, C.-W. Lin, C.-C. Lin, C.-C. Chen, A. S. C. Chan, W. T. Wong, J. Am. Chem. Soc., 2000, 122, 11513-11514.

DOI: 10.1021/ja000163n

see article for more reactions


A chiral atropisomeric dipyridylphosphine ligand (P-phos) forms well-defined ruthenium complexes that offer high enantioselectivities in the catalytic hydrogenation of 2-(6'-methoxy-2'-naphthyl)propenoic
acid and β-ketoesters.

see article for more examples

Key Words

reduction of carbonyl compounds, hydrogen

ID: J48-Y2000