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A Novel Cu-Assisted Cycloisomerization of Alkynyl Imines: Efficient Synthesis of Pyrroles and Pyrrole-Containing Heterocycles

Alexander V. Kel'in, Anna W. Sromek and Vladimir Gevorgyan*

*Department of Chemistry, University of Illinois at Chicago 845 West Taylor Street, Chicago, Illinois 60607-7061, USA, Email:

A. V. Kel'in, A. W. Sromek, V. Gevorgyan, J. Am. Chem. Soc., 2001, 123, 2074-2075.

DOI: 10.1021/ja0058684

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A general and efficient Cu-assisted cycloisomerization of alkynyl imines enables an efficient synthesis of pyrroles and various types of fused heteroaromatic compounds.

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proposed catalytic cycle

Low Temperature Organocopper-Mediated Two-Component Cross Coupling/Cycloisomerization Approach Toward N-Fused Heterocycles

D. Chernyak, S. B. Gadamsetty, V. Gevorgyan, Org. Lett., 2008, 10, 2307-2310.

Key Words

pyrroles, indolizines

ID: J48-Y2001