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Screening of Homogeneous Catalysts by Fluorescence Resonance Energy Transfer. Identification of Catalysts for Room-Temperature Heck Reactions

James P. Stambuli, Shaun R. Stauffer, Kevin H. Shaughnessy and John F. Hartwig*

*Department of Chemistry, Yale University P.O. Box 208107, New Haven, Connecticut 06520-8107

J. P. Stambuli, S. R. Stauffer, K. H. Shaughnessy, J. F. Hartwig, J. Am. Chem. Soc., 2001, 123, 2677-2678.

DOI: 10.1021/ja0058435

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A method to screen for transition metal-catalyzed reactions based on Fluorescence Resonance Energy Transfer (FRET) was used to identify catalysts for room-temperature Heck reactions of aryl bromides.

see article for more examples

FRET assay with a reagent containing a fluorophore and a second containing a quencher

An Efficient and General Method for the Heck and Buchwald-Hartwig Coupling Reactions of Aryl Chlorides

D.-H. Lee, A. Taher, S. Hossain, M.-J. Jin, Org. Lett., 2011, 13, 5540-5543.

Palladium-Catalyzed Arylation of Ethyl Cyanoacetate. Fluorescence Resonance Energy Transfer as a Tool for Reaction Discovery

S. R. Stauffer, N. A. Beare, J. P. Stambuli, J. F. Hartwig, J. Am. Chem. Soc., 2001, 123, 4641-4642.

Key Words

Heck reaction

ID: J48-Y2001