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The First General Method for Palladium-Catalyzed Negishi Cross-Coupling of Aryl and Vinyl Chlorides:  Use of Commercially Available Pd(P(t-Bu)3)2 as a Catalyst

Chaoyang Dai and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

C. Dai, G. C. Fu, J. Am. Chem. Soc., 2001, 123, 2719-2724.

DOI: 10.1021/ja003954y

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Commercially available Pd(P(t-Bu)3)2 catalyzes an effecient Negishi cross-coupling of a wide range of aryl and vinyl chlorides with aryl- and alkylzinc reagents. The process tolerates nitro groups, and  efficiently generates sterically hindered biaryls.

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Key Words

Negishi Coupling

ID: J48-Y2001