The First General Method for Palladium-Catalyzed Negishi Cross-Coupling of Aryl and Vinyl Chlorides: Use of Commercially Available Pd(P(t-Bu)3)2 as a Catalyst
Chaoyang Dai and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
C. Dai, G. C. Fu, J. Am. Chem. Soc., 2001, 123, 2719-2724.
DOI: 10.1021/ja003954y
see article for more reactions
Abstract
Commercially available Pd(P(t-Bu)3)2 catalyzes an effecient Negishi cross-coupling of a wide range of aryl and vinyl chlorides with aryl- and alkylzinc reagents. The process tolerates nitro groups, and efficiently generates sterically hindered biaryls.
see article for more examples
Key Words
ID: J48-Y2001
