Synthesis of α-Amido Ketones via Organic Catalysis: Thiazolium-Catalyzed Cross-Coupling of Aldehydes with Acylimines
Jerry A. Murry*, Doug E. Frantz*, Arash Soheili, Richard Tillyer, Edward J. J. Grabowski and Paul J. Reider
*Process Research Department Merck Research Laboratories, Merck and Co. Inc. P.O. Box 2000, Rahway, New Jersey 07065,
USA,
Email: jerry.murry
amgen.com, doug.frantzutsa.edu
J. A. Murry, D. E. Frantz, A. Soheili, R. Tillyer, E. J. J. Grabowski, P. J. Reider, J. Am. Chem. Soc., 2001, 123, 9696-9697.
DOI: 10.1021/ja0165943
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Abstract
A general and convenient thiazolium-catalyzed cross-coupling of various aldehydes with acylimines derived from sulfonylamides provides ready access to structurally diverse α-amido ketones.
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proposed mechanism
Key Words
α-amino ketones, Stetter reaction, organocatalysis
ID: J48-Y2001
