Direct Atom-Efficient Esterification between Carboxylic Acids and Alcohols Catalyzed by Amphoteric, Water-Tolerant TiO(acac)2
Chien-Tien Chen* and Yogesh S. Munot
*Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 11650, Email: chefv043ntnu.edu.tw
C.-T. Chen, Y. S. Munot, J. Org. Chem., 2005, 70, 8625-8627.
Various water-tolerant oxometallic species were examined as catalysts for an esterification in 1:1 stoichiometry. TiO(acac)2 tolerates many functional groups and offers a mild and chemoselective condensation of various, 1°-2° alkyl and aryl alcohols with 1°-3° alkyl and aryl carboxylic acids.
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