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CuI/L-Proline-Catalyzed Coupling Reactions of Aryl Halides with Activated Methylene Compounds

Xiaoan Xie, Guorong Cai and Dawei Ma*

*State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, Email:

X. Xie, G. Cai, D. Ma, Org. Lett., 2005, 7, 4693-4695.

DOI: 10.1021/ol0518838 (free Supporting Information)


2-aryl-1,3-dicarbonyl compounds are produced in good yields by a CuI/L-proline-catalyzed arylation of activated methylene compounds with aryl iodides and aryl bromides in DMSO at 40-50C in the presence of Cs2CO3.

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Key Words

Arylation, active methylene compounds

ID: J54-Y2005-1690