Pd-Catalyzed Silicon Hydride Reductions of Aromatic and Aliphatic Nitro Groups
Ronald J. Rahaim, Jr. and Robert E. Maleczka, Jr.*
*Department of Chemistry, Michigan State University, East Lansing, Michigan
48824, Email: maleczka
chemistry.msu.edu
R. J. Rahaim, R. E. Maleczka, Jr., Org. Lett., 2005, 7, 5087-5090.
DOI: 10.1021/ol052120n
see article for more examples
Abstract
Palladium-catalyzed reduction of aromatic nitro groups to amines can be accomplished in high yield, with wide functional group tolerance and short reaction times at r.t. using aqueous potassium fluoride and polymethylhydrosiloxane (PMHS) for aromatic nitro groups. Aliphatic nitro compounds are reduced to the corresponding hydroxylamines using triethylsilane instead of PMHS/KF.
see article for more examples
Key Words
Reduction of nitro compounds, Polymethylhydrosiloxane, Triethylsilane
ID: J54-Y2005-1800
