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Vanadium-Catalyzed Sulfur Oxidation/Kinetic Resolution in the Synthesis of Enantiomerically Pure Alkyl Aryl Sulfoxides

Carmelo Drago, Lorenzo Caggiano, Richard F. W. Jackson*

*Department of Chemistry, Dainton Building, University of Sheffield, Sheffield, S3 7HF, UK, Email:

C. Drago, L. Caggiano, R. F. W. Jackson, Angew. Chem. Int. Ed., 2005, 44, 7221-7223.

DOI: 10.1002/anie.200503046


The combination of very high ee values with high yield, the consequence of an efficient initial asymmetric oxidation followed by an efficient kinetic resolution, makes the reported system very practical for the asymmetric oxidation of simple akyl aryl sulfides.

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Key Words

asymmetric catalysis, kinetic resolution, oxidation, sulfoxides, vanadium, hydrogen peroxide

ID: J06-Y2005-1850