Vanadium-Catalyzed Sulfur Oxidation/Kinetic Resolution in the Synthesis of Enantiomerically Pure Alkyl Aryl Sulfoxides
Carmelo Drago, Lorenzo Caggiano, Richard F. W. Jackson*
*Department of Chemistry, Dainton Building, University of Sheffield, Sheffield, S3 7HF, UK, Email: r.f.w.jacksonshef.ac.uk
C. Drago, L. Caggiano, R. F. W. Jackson, Angew. Chem. Int. Ed., 2005, 44, 7221-7223.
DOI: 10.1002/anie.200503046 (free Supporting Information)
The combination of very high ee values with high yield, the consequence of an efficient initial asymmetric oxidation followed by an efficient kinetic resolution, makes the reported system very practical for the asymmetric oxidation of simple akyl aryl sulfides.
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asymmetric catalysis, kinetic resolution, oxidation, sulfoxides, vanadium, hydrogen peroxide