Simple, Rapid Procedure for the Synthesis of Chloromethyl Methyl Ether and Other Chloro Alkyl Ethers
Martin A. Berliner* and Katherine Belecki
*Chemical Research and Development, Pfizer Global Research and Development, Groton Labs, Groton, Connecticut 06340, Email: martin.a.berlinerpfizer.com
M. A. Berliner, K. Belecki, J. Org. Chem., 2005, 70, 9618-9621.
DOI: 10.1021/jo051344g (free Supporting Information)
0.01 mol-% Zinc(II) salts catalyze the reaction between acetals and acid halides to provide haloalkyl ethers in near-quantitative yield in 1 - 4 h. The solutions of haloalkyl ethers can be utilized directly in reactions in which the presence of the ester byproduct does not interfere. Excess carcinogenic haloalkyl ether is destroyed on workup.
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