A Practical Preparation of 2-Hydroxymethyl-2-cyclopenten-1-one by Morita-Baylis-Hillman Reaction
Hisanaka Ito*, Yosuke Takenaka, Shouhei Fukunishi, Kazuo Iguchi
*School of Life Science, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Email: itohisals.toyaku.ac.jp
H. Ito, Y. Takenaka, S. Fukunishi, K. Iguchi, Synthesis, 2005, 3035-3038.
Tributylphosphine or dimethylphenylphosphine catalyzed the Morita-Baylis-Hillman reaction of 2-cyclopenten-1-one with 1.2 equivalents of formalin to give 2-hydroxymethyl-2-cyclopenten-1-one within a short period and in an excellent yield. The efficiency of the reaction was strongly dependent on the solvent system.
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