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Efficient Palladium-Catalysed Enamide Synthesis from Enol Triflates and Enol Tosylates

Michael C. Willis*, Gareth N. Brace, Ian P. Holmes

*Department of Chemistry, University of Bath, Bath, BA2 7AY, UK, Email:

M. C. Willis, G. N. Brace, I. P. Holmes, Synthesis, 2005, 3229-3234.

DOI: 10.1055/s-2005-918480


Catalysts generated from Pd2(dba)3 and biphenyl ligands efficiently promote the coupling of amides and carbamates with unactivated vinyl triflates and tosylates, to provide enamides in good to excellent yields.

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Key Words

enamides, carbamates, palladium, catalysis, enol triflates, enol tosylates

ID: J66-Y2005-2080