Aerobic Oxidative Cyclization under Pd(II) Catalysis: A Regioselective Approach to Heterocycles
Kai-Tai Yip, Jin-Heng Li, On-Yi Lee and Dan Yang*
*Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China, Email: yangdanhku.hk
K.-T. Yip, J.-H. Li, O.-Y. Lee, D. Yang, Org. Lett., 2005, 7, 5717-5719.
DOI: 10.1021/ol052529c (free Supporting Information)
An efficient and regioselective Yb(OTf)3-promoted palladium-catalyzed oxidative cyclization of γ-heteroalkenyl β-keto amides has been developed. Under simple aerobic condition, various six-, seven-, and eight-membered-ring N- and O-heterocycles were obtained in excellent yield.
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