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Ionic Liquid-Promoted, Highly Regioselective Heck Arylation of Electron-Rich Olefins by Aryl Halides

Jun Mo, Lijin Xu and Jianliang Xiao*

*Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L69 7ZD, U.K., Email: j.xiaoliv.ac.uk

J. Mo, L. Xu, J. Xiao, J. Am. Chem. Soc., 2005, 127, 751-760.

DOI: 10.1021/ja0450861 (free Supporting Information)


Abstract

Palladium-catalyzed regioselective Heck arylation of various electron-rich olefins has been accomplished in imidazolium ionic liquids with a wide range of aryl bromides and iodides. The reaction proceeded with high efficiency and remarkable regioselectivity. The chemistry provides a simple, effective method for preparing branched olefins and contributes to the extension of the Heck reaction to a wider range of substrates.

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The Heck Reaction of Electron-Rich Olefins with Regiocontrol by Hydrogen-Bond Donors

J. Mo, J. Xiao, Angew. Chem. Int. Ed., 2006, 45, 4152-4157.


Key Words

Ionic Liquids, Heck Reaction, Aryl Ketones


ID: J48-Y2005-2180