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Multicomponent One-Pot Procedure for the Synthesis of Free α-Chiral Amines from Aldehydes

Alexandre Côté and André B. Charette*

*Département de Chimie, Université de Montréal, P.O. 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7, Email:

A. Cote, A. B. Charette, J. Org. Chem., 2005, 70, 10864-10867.

DOI: 10.1021/jo0516483


The synthesis of free α-chiral amines by a one-pot multicomponent procedure involves the formation of N-diphenylphosphinoylimines from commercially available starting materials and the subsequent enantioselective addition of diakylzinc reagents using an air-stable precatalyst complex.

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Key Words

Primary Amines, Addition, Benzylamines, Multicomponent Reactions

ID: J48-Y2005-2110