Palladium-Catalyzed Asymmetric Amination and Imidation of 2,3-Allenyl Phosphates
Yasushi Imada,* Masayuki Nishida, Koji Kutsuwa, Shun-Ichi Murahashi and Takeshi Naota
*Department of Chemistry, Graduate School of Engineering Science, Osaka University Machikaneyama, Toyonaka, Osaka 560-8531, Japan, Email: imadachem.es.osaka-u.ac.jp
Y. Imada, M. Nishida, K. Kutsuwa, S.-I. Murahashi, T. Naota, Org. Lett., 2005, 7, 5837-5839.
DOI: 10.1021/ol0523502 (free Supporting Information)
An efficient palladium-catalyzed asymmetric amination of 2,3-allenyl phosphates with nitrogen nucleophiles such as amines, hydroxylamines, and imides can be performed in presence of SEGPHOS or MeOBIPHEP ligand, affording the corresponding optically active 1-aminated derivatives with high enantiomeric excess.
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