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A Convenient and Efficient One-Pot Synthesis of 3-Acylisoxazoles Using Iron(III) Salts

Ken-ichi Itoh, Hiroshi Sakamaki, Noriko Nakazato, Atsuo Horiuchi, Ernst Horn, C. Akira Horiuchi*

*Department of Chemistry, Rikkyo (St. Paul’s) University, 3-34-1 Nishi-Ikebukuro, Toshima-ku Tokyo 171-8501, Japan, Email:

K.-I. Itoh, H. Sakamaki, N. Nakazato, A. Horiuchi, E. Horn, C. A. Horiuchi, Synthesis, 2005, 3541-3548.

DOI: 10.1055/s-2005-916041


3-Acylisoxazoles were synthesized by the reaction of alkenes or alkynes with ketones (acetone or acetophenone), as both a reagent and the solvent, by three methods: iron(III) nitrate under reflux, iron(III) salt-nitrogen dioxide (NO2) at room temperature, and iron(III) nitrate under microwave irradiation (MW).

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Key Words

alkenes, alkynes, ketones, iron(III) nitrate, isoxazoles, isoxazolines, multicomponent reactions

ID: J66-Y2005-2190