A Convenient and Efficient One-Pot Synthesis of 3-Acylisoxazoles Using Iron(III) Salts
Ken-ichi Itoh, Hiroshi Sakamaki, Noriko Nakazato, Atsuo Horiuchi, Ernst Horn, C. Akira Horiuchi*
*Department of Chemistry, Rikkyo (St. Paul’s) University, 3-34-1 Nishi-Ikebukuro, Toshima-ku Tokyo 171-8501, Japan, Email: horiuchirikkyo.ac.jp
K.-I. Itoh, H. Sakamaki, N. Nakazato, A. Horiuchi, E. Horn, C. A. Horiuchi, Synthesis, 2005, 3541-3548.
3-Acylisoxazoles were synthesized by the reaction of alkenes or alkynes with ketones (acetone or acetophenone), as both a reagent and the solvent, by three methods: iron(III) nitrate under reflux, iron(III) salt-nitrogen dioxide (NO2) at room temperature, and iron(III) nitrate under microwave irradiation (MW).
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