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Highly Efficient One-Pot Synthesis of N-Sulfonylamidines by Cu-Catalyzed Three-Component Coupling of Sulfonyl Azide, Alkyne, and Amine

Imhyuck Bae, Hoon Han and Sukbok Chang*

*Center for Molecular Design and Synthesis, Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejon 305-701 Republic of Korea, Email:

I. Bae, H. Han, S. Chang, J. Am. Chem. Soc., 2005, 127, 2038-2039.

DOI: 10.1021/ja0432968


A highly efficient, mild, copper-catalyzed multicomponent reaction for the synthesis of N-sulfonylamidines has been developed. This reaction has an extremely wide scope with regard to all three coupling components of alkyne, sulfonyl azide, and amine. Two plausible mechanistic pathways are discussed.

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Key Words

Amidines, Multicomponent Reactions

ID: J48-Y2005-2270