Highly efficient methods for the one-pot synthesis of β-substituted enones
William J. Kerr*, Colin M. Pearson and Graeme J. Thurston
*WestCHEM, Department of Pure and Applied Chemistry, University of Strathcycle, 295 Cathedral Street, Glasgow, Scotland, UK G1 1XL, Email: w.kerrstrath.ac.uk
W. J. Kerr, C. M. Person, G. J. Thurston, Org. Biomol. Chem., 2006, 4, 47-50.
see article for more reactions
A mild and practically-convenient one-pot procedure for the direct β-substitution of enones has been developed using a conjugate addition-oxidation strategy with a full range of copper-based reagents (R2CuLi, RCu.SMe, RCu, R(2-thienyl)Cu(CN)Li2) and N-tert-butylphenylsulfinimidoyl chloride. Cyclic and acyclic, alkyl- and aryl-substituted enones are delivered in good to excellent yields.
see article for more examples