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'In situ'; Generated 'HCl'; - An Efficient Catalyst for Solvent-Free Hantzsch Reaction at Room Temperature: Synthesis of New Dihydropyridine Glycoconjugates

G. V. M. Sharma*, K. Laxmi Reddy, P. Sree Lakshmi, Palakodety Radha Krishna

*D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email:

G. V. M. Sharma, K. L. Reddy, P. S. Lakshmi, P. R. Krishna, Synthesis, 2006, 55-58.

DOI: 10.1055/s-2005-921744


HCl, generated in situ from 2,4,6-trichloro[1,3,5]triazine (TCT, cyanuric chloride), catalyzed a solvent free Hantzsch reaction at room temperature with enhanced reaction rates. The reaction conditions allow facile preparation of glycoconjugates of dihydropyridines under mild reaction conditions in high yields.

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Key Words

dihydropyridines, glycoconjugates, Hantzsch reaction, 2,4,6-trichloro[1,3,5]triazine (TCT - cyanuric chloride)

ID: J66-Y2006-060