Organic Chemistry Portal



A Highly Enantio- and Diastereoselective Catalytic Intramolecular Stetter Reaction

Javier Read de Alaniz and Tomislav Rovis*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, Email:

J. Read de Alaniz, T. Rovis, J. Am. Chem. Soc., 2005, 127, 6284-6289.

DOI: 10.1021/ja0425132


A highly enantio- and diastereoselective intramolecular Stetter reaction has been developed. Aliphatic and aromatic aldehydes and a broad range of trisubstituted Michael acceptors have been found to afford the desired products in good overall yield with high enantio- and diastereoselectivity.

see article for more examples

Key Words

Stetter Reaction, Organocatalysis, Cyclopentanones, O-Heterocycles, Ketones

ID: J48-Y2005-2330