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Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

Cheng-Sheng Jia, Ze Zhang, Shu-Jiang Tu and Guan-Wu Wang*

*Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China, Email:

C.-S. Jia, Z. Zhang, S.-J. Tu, G.-W. Wang, Org. Biomol. Chem., 2006, 4, 104-110.

DOI: 10.1039/b513721g


A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedlšnder condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions.

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Key Words

Friedlaender Synthesis, Microwave Synthesis, Quinolines

ID: J52-Y2006-110