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Expedited Palladium-Catalyzed Amination of Aryl Nonaflates through the Use of Microwave-Irradiation and Soluble Organic Amine Bases

Rachel E. Tundel, Kevin W. Anderson and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139,

R. E. Tundel, K. W. Anderson, S. L. Buchwald, J. Org. Chem., 2006, 71, 430-433.

DOI: 10.1021/jo052131u

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Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using soluble amine bases resulted in good to excellent yields of arylamines in short reaction times.

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Key Words

Microwave Synthesis, Buchwald-Hartwig Coupling, Arylamines, Amidation

ID: J42-Y2006-120