Expedited Palladium-Catalyzed Amination of Aryl Nonaflates through the Use of Microwave-Irradiation and Soluble Organic Amine Bases
Rachel E. Tundel, Kevin W. Anderson and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
Massachusetts 02139, sbuchwal
mit.edu
R. E. Tundel, K. W. Anderson, S. L. Buchwald, J. Org. Chem., 2006, 71, 430-433.
DOI: 10.1021/jo052131u
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Abstract
Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using soluble amine bases resulted in good to excellent yields of arylamines in short reaction times.
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Key Words
Microwave Synthesis, Buchwald-Hartwig Coupling, Arylamines, Amidation
ID: J42-Y2006-120
