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Phosphorus Pentasulfide: A Mild and Versatile Reagent for the Preparation of Thioamides from Nitriles

Babak Kaboudin*, Dawood Elhamifar

*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran, Email:

B. Kaboudin, D. Elhamifar, Synthesis, 2006, 224-226.

DOI: 10.1055/s-2005-918507


A simple, efficient, and new method has been developed for the synthesis of thioamides from nitriles. The reaction of a variety of aromatic and aliphatic nitriles in the presence of phosphorus pentasulfide afforded the corresponding thioamides in high yields. This method is easy, rapid, and high-yielding for the synthesis of thioamides from nitriles.

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Ammonium Phosphorodithioate: A Mild, Easily Handled, Efficient, and Air-Stable Reagent for the Conversion of Amides into Thioamides

B. Kaboudin, L. Malekzadeh, Synlett, 2011, 2807-2810.

Key Words

thioamides, nitriles, phosphorus pentasulfide, phosphorodithioates, addition reactions

ID: J66-Y2006-170