Phosphorus Pentasulfide: A Mild and Versatile Reagent for the Preparation of Thioamides from Nitriles
Babak Kaboudin*, Dawood Elhamifar
*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran, Email: kaboudiniasbs.ac.ir
B. Kaboudin, D. Elhamifar, Synthesis, 2006, 224-226.
A simple, efficient, and new method has been developed for the synthesis of thioamides from nitriles. The reaction of a variety of aromatic and aliphatic nitriles in the presence of phosphorus pentasulfide afforded the corresponding thioamides in high yields. This method is easy, rapid, and high-yielding for the synthesis of thioamides from nitriles.
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B. Kaboudin, L. Malekzadeh, Synlett, 2011, 2807-2810.