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Cobalt-Catalyzed Reductive Coupling of Saturated Alkyl Halides with Activated Alkenes

Paritosh Shukla, Yun-Chu Hsu and Chien-Hong Cheng*

*Department of Chemistry, National Tsing Hua University, Hsinchu 30043, Taiwan, chchengmx.nthu.edu.tw

P. Shukla, Y.-C. Hsu, C.-H. Cheng, J. Org. Chem., 2006, 71, 655-658.

DOI: 10.1021/jo052065w (free Supporting Information)


Abstract

An efficient cobalt-catalyzed reductive coupling reaction of alkyl halides with alkenes bearing electron-withdrawing groups in the presence of water and zinc powder in acetonitrile gave the corresponding Michael-type addition products in high yields. The mechanism is discussed.

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Key Words

Esters, Nitriles, Sulfones, Zinc


ID: J42-Y2006-200