Direct Carbon-Carbon Bond Formation from Alcohols and Active Methylenes, Alkoxyketones, or Indoles Catalyzed by Indium Trichloride

Makoto Yasuda, Toshio Somyo, Akio Baba*

*Department of Applied Chemistry and Handai Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan, E-mail: babachem.eng.osaka-u.ac.jp

M. Yasuda, T. Somyo, A. Baba, Angew. Chem. Int. Ed., 2006, 45, 793-796.

DOI: 10.1002/anie.200503263

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Abstract

A mild and direct indium-catalyzed process for the C-C bond formation from alcohols and active methylenes, alkoxyketones or indoles was developed.

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Direct Coupling Reaction between Alcohols and Silyl Compounds: Enhancement of Lewis Acidity of Me₃SiBr Using InCl₃

T. Saito, Y. Nishimoto, M. Yasuda, A. Baba, J. Org. Chem., 2006, 71, 8516-8522.

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Key Words

active methylenes, allylic substitutions, benzylic substitutions, alcohols, CC coupling, indium, synthetic methods

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ID: J06-Y2006-220