Scandium triflate catalyzed cycloaddition of imines with 1,1-cyclopropanediesters: efficient and diastereoselective synthesis of multisubstituted pyrrolidines
Yan-Biao Kang, Yong Tang* and Xiu-Li Sun
*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032, China, Email: tangymail.sioc.ac.cn
Y.-B. Kang, Y. Tang, X.-L. Sun, Org. Biomol. Chem., 2006, 4, 299-301.
DOI: 10.1039/b512195g (free Supporting Information)
A tandem ring-opening-cyclization reaction of cyclopropanes with imines in the presence of 5 mol% of scandium triflate was developed for the highly diastereoselective synthesis of multisubstituted pyrrolidines.
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