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Scandium triflate catalyzed cycloaddition of imines with 1,1-cyclopropanediesters: efficient and diastereoselective synthesis of multisubstituted pyrrolidines

Yan-Biao Kang, Yong Tang* and Xiu-Li Sun

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032,  China, Email: tangymail.sioc.ac.cn

Y.-B. Kang, Y. Tang, X.-L. Sun, Org. Biomol. Chem., 2006, 4, 299-301.

DOI: 10.1039/b512195g (free Supporting Information)


Abstract

A tandem ring-opening-cyclization reaction of cyclopropanes with imines in the presence of 5 mol% of scandium triflate was developed for the highly diastereoselective synthesis of multisubstituted pyrrolidines.

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Key Words

Pyrrolidines


ID: J52-Y2006-210