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Synthesis of Enantiopure Allylamines by Reductive Alkylation of Amino Epoxides with Organolithium Reagents

José M. Concellón,* José Ramón Suárez and Virginia del Solar

*Departamento de Química Orgánica e Inorgánica, Facultad de Química Universidad de Oviedo, Julián Clavería, 8, 33071 Oviedo, Spain, Email:

J. M. Concellon, J. R. Suarez, V. del Solar, Org. Lett., 2006, 8, 349-351.

DOI: 10.1021/ol0529602


Opening of the epoxide ring of enantiopure (2R,1'S)-2-(1-aminoalkyl)epoxides with different organolithium compounds gave allylamines with total selectivity and in high yields.

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Key Words

Allylamines, Alkylation

ID: J54-Y2006-350