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Enantioselective Nazarov Reactions through Catalytic Asymmetric Proton Transfer

Guangxin Liang and Dirk Trauner*

*Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720-1460, Email:

G. Liang, D. Trauner, J. Am. Chem. Soc., 2004, 126, 9544-9545.

DOI: 10.1021/ja0476664


A catalytic asymmetric Nazarov reaction is described that requires only 10 mol % of a chiral Lewis acid and proceeds with ee's between 72% and 97%.

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Key Words

Enones, Nazarov Cyclization

ID: J48-Y2005-2430