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A Convenient Method for the Preparation of Benzyl Isocyanides

Yoshikazu Kitano*, Tetsuya Manoda, Teppei Miura, Kazuhiro Chiba, Masahiro Tada

*Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan, Email:

Y. Kitano, T. Manoda, T. Miura, K. Chiba, M. Tada, Synthesis, 2006, 405-410.

DOI: 10.1055/s-2005-918517


Treatment of benzyl halides with silver salts and trimethylsilyl cyanide followed by cleavage of the carbon-silicon bond directly afforded the corresponding isocyanides.

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Key Words

benzyl isocyanides, benzyl halides, silver salts, tri­methylsilyl cyanide, perchlorate

ID: J66-Y2006-360