A Versatile Method for Suzuki Cross-Coupling Reactions of Nitrogen Heterocycles

Noriaki Kudo, Mauro Perseghini, Gregory C. Fu

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Email: gcfmit.edu

N. Kudo, M. Perseghini, G. C. Fu, Angew. Chem. Int. Ed., 2006, 45, 1282-1284.

DOI: 10.1002/anie.200503479

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Abstract

A versatile Suzuki reaction of nitrogen-containing heterocyclic cross-coupling partners was developed. The method allowed the conversion of boronic acids, boronates, trifluoroborates even with unactivated aryl chlorides and tolerated various unprotected functionalities including NH₂- and OH-substituted pyridines and indoles

see article for more examples

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Versatile Catalysts for the Suzuki Cross-Coupling of Arylboronic Acids with Aryl and Vinyl Halides and Triflates under Mild Conditions

A. F. Littke, C. Dai, G. C. Fu, J. Am. Chem. Soc., 2000, 122, 4020-4028.

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Key Words

Suzuki Coupling, N-Heterocycles, homogeneous catalysis, nitrogen, palladium

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ID: J06-Y2006-320