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Amidination of Amines under Microwave Conditions Using Recyclable Polymer-Bound 1H-Pyrazole-1-carboxamidine

Wladimir Solodenko, Patrick Bröker, Josef Messinger, Uwe Schön, Andreas Kirschning*

*Institut für Organische Chemie, Universität Hannover, Schneiderberg 1b, 30167 Hannover; Germany, Email:

W. Solodenko, P. Bröker, J. Messinger, U. Schön, A. Kirschning, Synthesis, 2006, 461-466.

DOI: 10.1055/s-2006-926284


A convenient one-step transformation of primary and secondary amines into the corresponding unprotected guanidines using 4-benzyl-3,5-dimethyl-1H-pyrazole-1-carboxamidine and its polymer-bound variant is described. The scopes and limitations of the method, the microwave-assistance of amidination as well as a recycling protocol are examined.

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Key Words

amines, guanidines, polymer-bound reagent, microwave-assisted synthesis, reagent regeneration

ID: J66-Y2006-440