Amidination of Amines under Microwave Conditions Using Recyclable Polymer-Bound 1H-Pyrazole-1-carboxamidine
Wladimir Solodenko, Patrick Bröker, Josef Messinger, Uwe Schön, Andreas Kirschning*
*Institut für Organische Chemie, Universität Hannover, Schneiderberg 1b, 30167 Hannover; Germany, Email: andreas.kirschningoci.uni-hannover.de
W. Solodenko, P. Bröker, J. Messinger, U. Schön, A. Kirschning, Synthesis, 2006, 461-466.
DOI: 10.1055/s-2006-926284
Abstract
A convenient one-step transformation of primary and secondary amines into the corresponding unprotected guanidines using 4-benzyl-3,5-dimethyl-1H-pyrazole-1-carboxamidine and its polymer-bound variant is described. The scopes and limitations of the method, the microwave-assistance of amidination as well as a recycling protocol are examined.
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Key Words
amines, guanidines, polymer-bound reagent, microwave-assisted synthesis, reagent regeneration
ID: J66-Y2006-440