Organic Chemistry Portal



A New Synthetic Approach to Phenol Derivatives: Use of Ring-Closing Olefin Metathesis

Kazuhiro Yoshida* and Tsuneo Imamoto*

*Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email:,

K. Yoshida, T. Imamoto, J. Am. Chem. Soc., 2005, 127, 10470-10471.

DOI: 10.1021/ja050853x (free Supporting Information)

see article for more reactions


Phenol derivatives were synthesized by ruthenium-catalyzed ring-closing metathesis of various 1,4,7-trien-3-ones and 1,5,7-trien-3-one as another precursor. Most of the phenols prepared could not be obtained easily by conventional methods.

see article for more examples

An Efficient Route to Benzene and Phenol Derivatives via Ring-Closing Olefin Metathesis

K. Yoshida, S. Horiuchi, N. Iwadate, F. Kawagoe, T. Imamoto, Synlett, 2007, 1561-1562.

Synthesis of 3-Hydroxypyridines Using Ruthenium-Catalyzed Ring-Closing Olefin Metathesis

K. Yoshida, F. Kawagoe, K. Hayashi, S. Horiuchi, T. Imamoto, A. Yanagisawa, Org. Lett., 2009, 11, 515-518.

Key Words

Ring-closing metathesis, Phenols, Cyclizations

ID: J48-Y2005-2480