Diversity-Oriented Synthesis of 3-Iodochromones and Heteroatom Analogues via ICl-Induced Cyclization
Chengxiang Zhou, Anton V. Dubrovsky and Richard C. Larock*
*Department of Chemistry, Iowa State University, Ames, Iowa 50011, Email: larockiastate.edu
C. Zhou, A. V. Dubrovsky, R. C. Larock, J. Org. Chem., 2006, 71, 1626-1632.
DOI: 10.1021/jo0523722 (free Supporting Information)
A mild ICl-induced cyclization of heteroatom-substituted alkynones provides a simple, highly efficient approach to various 3-iodochromones, iodothiochromenones, iodoquinolinones and analogues in good to excellent yields. Subsequent palladium-catalyzed transformations afford a rapid increase in molecular complexity.
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