Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides
Forrest O. Arp and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
Massachusetts 02139, Email: gcf
mit.edu
F. O. Arp, G. C. Fu, J. Am. Chem. Soc., 2005, 127, 10482-10483.
DOI: 10.1021/ja053751f
Abstract
An enantioselective nickel-catalyzed Negishi cross-coupling of racemic secondary benzylic bromides and chlorides is described. The catalyst components are commercially available and air-stable, and the reaction is not highly oxygen- or moisture-sensitive.
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Key Words
Negishi Coupling, Benzylation, Indanes
ID: J48-Y2005-2510
