An Iron-Containing Ionic Liquid as Recyclable Catalyst for Aryl Grignard Cross-Coupling of Alkyl Halides

Katharina Bica and Peter Gaertner*

*Department of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, A-1060 Vienna, Austria, Email: peter.gaertnertuwien.ac.at

K. Bica, P. Gaertner, Org. Lett., 2006, 8, 733-735.

DOI: 10.1021/ol052965z

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Abstract

Butylmethylimidazolium tetrachloroferrate (bmim-FeCl₄) was found to be a very effective and completely air stable catalyst for the biphasic Grignard cross-coupling with primary and secondary alkyl halides bearing α-hydrogens. The product was simply isolated in the ethereal layer and the ionic liquid catalyst was successfully recycled four times.

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Key Words

Grignard Reagents, Substituted Arenes

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ID: J54-Y2006-550