Hydrogen Bond Catalyzed Direct Reductive Amination of Ketones
Dirk Menche,* Jorma Hassfeld, Jun Li, Gerd Menche, Antje Ritter and Sven Rudolph
*Gesellschaft für Biotechnologische Forschung mbH, Medzinische Chemie,
Mascheroder Weg 1, D-38124 Braunschweig, Germany, Email: dme05
gbf.de
D. Menche, J. Hassfeld, J. Li, G. Menche, A. Ritter, S. Rudolph, Org. Lett., 2006, 8, 741-744.
DOI: 10.1021/ol053001a
Abstract
A biomimetic direct reductive amination of ketones relies on selective imine activation by hydrogen bond formation with thiourea as hydrogen bond donor and utilizes the Hantzsch ester for transfer hydrogenation. The method allows the efficient synthesis of structurally diverse amines.
see article for more examples
Thiourea-Catalyzed Direct Reductive Amination of Aldehydes
D. Menche, F. Arikan, Synlett, 2006, 841-844.
Key Words
reductive amination, Hantzsch ester, organocatalysis
ID: J54-Y2006-550
