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Gold(I)-Catalyzed Intramolecular Hydroamination of Alkenyl Carbamates

Xiaoqing Han, Ross A. Widenhoefer*

*P. M. Gross Chemical Laboratory, Duke University, Durham, NC 27708-0346, USA, Email:

X. Han, R. A. Widenhoefer, Angew. Chem. Int. Ed., 2006, 45, 1747-1749.

DOI: 10.1002/anie.200600052 (free Supporting Information)


A mild, effective gold(I)-catalyzed hydroamination of unactivated olefins to form protected nitrogen heterocycles has been developed. The substrate scope is broader than in reactions realized with late-transition-metal catalyst systems.

see article for more examples

Room Temperature Hydroamination of N-Alkenyl Ureas Catalyzed by a Gold(I) N-Heterocyclic Carbene Complex

C. F. Bender, R. A. Widenhoefer, Org. Lett., 2006, 8, 5303-5305.

Highly Active Au(I) Catalyst for the Intramolecular exo-Hydrofunctionalization of Allenes with Carbon, Nitrogen, and Oxygen Nucleophiles

Z. Zhang, C. Liu, R. E. Kinder, X. Han, H. Qian, R. A. Widenhoefer, J. Am. Chem. Soc., 2006, 128, 9066-9073.

Key Words

alkenes, amines, gold, homogeneous catalysis, hydroamination, cyclic amines

ID: J06-Y2006-660