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Triphenylphosphine as a Ligand for Room-Temperature Ni(0)-Catalyzed Cross-Coupling Reactions of Aryl Chlorides with Arylboronic Acids

Zhen-Yu Tang and Qiao-Sheng Hu*

*Department of Chemistry, College of Staten Island and the Graduate Center of the City University of New York, Staten Island, New York 10314, Email:

Z.-Y. Tang, Q.-S. Hu, J. Org. Chem., 2006, 71, 2167-2169.

DOI: 10.1021/jo052369i

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Room-temperature Ni(0)-catalyzed cross-coupling reactions of deactivated aryl chlorides with arylboronic acids with inexpensive triphenylphosphine as ligand have been accomplished in good to excellent yields. Highly active nickel catalysts were obtained through the reduction of air-stable Ni(PPh3)2Cl2 with n-BuLi in the presence of an aryl chloride.

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ID: J42-Y2006-670