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A Highly Efficient and Direct Approach for Synthesis of Enantiopure β-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes

Yu-Wu Zhong, Yi-Zhou Dong, Kai Fang, Kenji Izumi, Ming-Hua Xu* and Guo-Qiang Lin

*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, Email:

Y.-W. Zhong, Y.-Z. Dong, K. Fang, K. Izumi, M.-H. Xu, G.-Q. Lin, J. Am. Chem. Soc., 2005, 127, 11956-11957.

DOI: 10.1021/ja054401w


A highly efficient, mild and practical approach for the synthesis of optically pure β-amino alcohols by the SmI2-induced reductive cross-coupling of various chiral N-tert-butanesulfinyl imines with aldehydes was developed.

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Key Words

1,2-amino alcohols, Samarium Diiodide

ID: J48-Y2005-2560