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Pd/C-Catalyzed Deoxygenation of Phenol Derivatives Using Mg Metal and MeOH in the Presence of NH4OAc

Hironao Sajiki,* Akinori Mori, Tomoteru Mizusaki, Takashi Ikawa, Tomohiro Maegawa and Kosaku Hirota

*Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan, Email: sajikigifu-pu.ac.jp

H. Sajiki, A. Mori, T. Mizusaki, T. Ikawa, T. Meagazwa, K. Hirota, Org. Lett., 2006, 8, 987-990.

DOI: 10.1021/ol060045q


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Abstract

A mild, versatile, Pd/C-catalyzed deoxygenation of phenolic hydroxyl groups via aryl triflates or mesylates using Mg metal in MeOH at room temperature was developed. The addition of NH4OAc dramatically affects the reactivity and reaction rate.

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Key Words

Deoxygenations


ID: J54-Y2006-740