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A Highly Enantioselective Lewis Basic Organocatalyst for Reduction of N-Aryl Imines with Unprecedented Substrate Spectrum

Zhouyu Wang, Xiaoxia Ye, Siyu Wei, Pengcheng Wu, Anjiang Zhang and Jian Sun*

*Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China, Email:

Z. Wang, X. Ye, S. Wei, P. Wu, A. Zhang, J. Sun, Org. Lett., 2006, 8, 999-1001.

DOI: 10.1021/ol060112g


L-Pipecolinic acid derived formamides are highly efficient and enantioselective Lewis basic organocatalysts for the mild reduction of various N-aryl imines with trichlorosilane.

see article for more examples

L-Piperazine-2-carboxylic Acid Derived N-Formamide as a Highly Enantioselective Lewis Basic Catalyst for Hydrosilylation of N-Aryl Imines with an Unprecedented Substrate Profile

Z. Wang, M. Cheng, P. Wu, S. Wei, J. Sun, Org. Lett., 2006, 8, 3045-3048.

Key Words

Reduction of Imines, Trichlorosilane, Organocatalysis

ID: J54-Y2006-760