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Asymmetric Alkynylation of Aldehydes Catalyzed by an In(III)/BINOL Complex

Ryo Takita, Kenichiro Yakura, Takashi Ohshima and Masakatsu Shibasaki*

*Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email:

R. Takita, K. Yakura, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 2005, 127, 13760-13761.

DOI: 10.1021/ja053946n (free Supporting Information)


Asymmetric alkynylation of aldehydes using catalytic amounts of In(III)/BINOL enables a broad range of substrate generality with high enantioselectivity due to the "bifunctional character" of the catalyst activating both substrates.

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Key Words

Propargylic Alcohols

ID: J48-Y2005-2590