One-Pot Synthesis of Trisubstituted Conjugated Dienes via Sequential Suzuki-Miyaura Cross-Coupling with Alkenyl- and Alkyltrifluoroborates
Gary A. Molander and Yasuo Yokoyama*
*Department of Chemistry, Faculty of Science and Technology, Sophia
University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan, Email: yasuo-y
sophia.ac.jp
G. A. Molander, Y. Yokoyama, J. Org. Chem., 2006, 71, 2493-2498.
DOI: 10.1021/jo052636k
Abstract
A sequential, palladium-catalyzed, stereoselective disubstitution of 1,1-dibromoalkenes
with various alkenyltrifluoroborates followed by alkyltrifluoroborates proceeds smoothly in
one pot under mild reaction conditions to provide the corresponding
trisubstituted, conjugated dienes in excellent yield.
see article for more examples
Key Words
Dienes, Suzuki Coupling, Trifluoroborates
ID: J42-Y2006-770
