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Flavin-Catalyzed Generation of Diimide: An Environmentally Friendly Method for the Aerobic Hydrogenation of Olefins

Yasushi Imada,* Hiroki Iida and Takeshi Naota

*Department of Chemistry, Graduate School of Engineering Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560-8531, Japan, Email:

Y. Imada, H. Iida, T. Naota, J. Am. Chem. Soc., 2005, 127, 14544-14545.

DOI: 10.1021/ja053976q (free Supporting Information)


Olefins can be hydrogenated by treatment with hydrazine in the presence of a 5-ethyl-3-methyllumiflavinium perchlorate catalyst under O2 atmosphere to give the corresponding hydrogenated products in excellent yields along with environmentally benign water and molecular nitrogen as the only waste products.

see article for more examples

Neutral Flavins: Green and Robust Organocatalysts for Aerobic Hydrogenation of Olefins

Y. Imada, T. Kitagawa, T. Ohno, H. Iida, T. Naota, Org. Lett., 2010, 12, 32-35.

Key Words

Hydrogenations, Hydrazine

ID: J48-Y2005-2610